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Instruments

DelsaMax Series

The DelsaMax Series of Light Scatter Analyzers offer incredible speed, reliability and precision for particle and nanoparticle characterization. Each instrument allows you to gain valuable insight into your samples through non-destructive testing of even the smallest quantities of materials.

DelsaMax are a family of instruments that utilize light scattering detection in order to determine the size distribution of particles within a sample population.

Light scattering is a highly sensitive technique that is biased by larger particles which makes it very useful for detecting particle aggregation and sample contamination. It is important to note that Light scattering, like Laser Diffraction, is an “ensemble” technique which does not measure individual particles but determines the size distribution within the population.

Whatever your needs there is a DelsaMax instrument for you.

DelsaMax PRO: Simultaneous Dynamic Light Scatter and Zeta Potential determination.

DelsaMax CORE: Static and Dynamic Light Scatter for size and molecular weight analysis.

Features

  • Dynamic and Static Light Scattering Detection
  • Rapid, non-destructive Zeta Potential analysis
  • Lowest sample volumes available as little as 1 μL needed for size analysis
  • Intuitive easy to use software

Applications

  • Protein Stability Analysis
  • Formulation testing
  • Nanoparticle characterization
  • Liposome and Exosome analysis
  • Polymer and macromolecule analysis
  • Aggregation detection

DelsaMax PRO

DelsaMax PRO Zeta Potential Dynamic Light Scattering Analyzer

The DelsaMax PRO allows simultaneous analysis of both particle size and zeta potential from sample volumes as small as 45 μL, in as little as one second.

The DelsaMax™ PRO utilizes Dynamic Light Scattering (DLS, sometimes referred to as Quasi-elastic Light Scattering QELS) to determine molecular size simultaneously with Phase Analysis Light Scatter (PALS) to determine Zeta Potential.

The incredible speed of the DelsaMax PRO comes in part from its 32 detector array which allows sensitive detection of particle motion in response to the applied electric field.

The rapid detection helps prevent sample degradation that can occur in other slower Zeta potential instruments due to the prolonged exposure of the sample to intense electric fields.

The DelsaMax PRO also utilizes a flow cell system requiring only 170 μL of sample and can be used in-line with industry standard auto-samplers for analysis of multiple formulation samples.

For challenging samples with high electrical conductivity that are prone to generating bubbles, the DelsaMax PRO can be used in conjunction with the DelsaMax ASSIST module.

Specifications

DelsaMax PRO 50 mW 532nm DPSS Laser
Molecular Size Determination 168º back scatter angle Avalanche Photodiode for DLS detection
Size Range 0.4 to 10,000 nm, hydrodynamic diameter (limited by particle sedimentation)
Molar Mass Range 5×107 g/mol (Da) (dependent on molecular shape model)
Minimum Sample Volume DLS 45 μL
Minimum Measurement Time 1 second
Zeta Potential Measurement 32 Detector Photodiode Array
Minimum Sample Volume PALS Flow cell: 170 μL, excluding tubing, Dip cell: 60 μL
Ionic Strength Range 0 to 50 mS/cm (4 times the conductivity of physiological saline)
Mobility Range No practical limit
Mobility Size Range 2 nm to 15 μm diameter
Mobility Sensitivity 1 mg/ mL Lysozyme
Minimum Measurement Time 1 second

DelsaMax CORE

DelsaMax CORE Light Scattering Analyzer for Particle Size and Molecular Weight

The DelsaMax CORE provides nanosizing of particles in samples as small as 1μL sample volumes.

The DelsaMax CORE measures Dynamic Light Scatter and Static Light Scatter from the same sample using 90 degree side scatter detectors.

Molecular size is determined by Dynamic Light Scattering (DLS) using an avalanche photodiode with readings requiring as little as 1 second.

Using a calibrated quartz cuvette Molecular Weight determination can be performed using Static Light Scattering (SLS) from as little as 1 μL of sample.

Specifications

DelsaMax CORE  100 mW 658 nm Diode Laser
Molecular Size Analysis Dynamic Light Scatter using 90° angle fiber coupled avalanche photodiode
DLS Size Range (Diameter) 0.2 to 2500 nm
Minimum Sensitivity 0.1 mg/ mL Lysozyme
Molecular Weight Analysis Static Lights Scatter using 90° angle photodiode
SLS Molecular Weight Range 300 to 106 Da (concentration dependent)
Minimum Sample Volume (DLS and SLS) 1 μL quartz cuvette,
4 μL disposable cuvette
Correlator 512 channels (100 nsec sampling time in a multi-tau layout)
Data Acquisition Time 1 to 3,600 seconds
Minimum Measurement Time 1 second
Sample temperature range Quartz Cuvette -15° C to 150° C
Diposable Cuvette 0° C to 80° C

DelsaMax ASSIST

DelsaMax ASSIST Cell Pressurization System

The DelsaMax ASSIST is an optional accessory for use with the DelsaMax PRO system when performing Zeta Potential measurements.

The DelsaMax ASSIST reduces bubbling in the sample solution by pressurizing the flow cell >30 fold above atmospheric pressure to reduce bubbles which can cause signal interference.

This is particularly useful for highly conductive samples or those requiring large voltages (low charge materials) which are prone to generating bubbles under high current.

DelsaMax Software

Designed for precision and accuracy, DelsaMax software features an intuitive interface with fully customizable autocorrelation analysis, a proprietary “normalization” algorithm and more.

License free so can be installed on multiple computers for off-line data analysis.

Allows remote network control of multiple instruments.

Training Courses

File/Info Title Ref. Number
DelsaMax

Videos

  • DelsaMax - Life Science Connect with Matt Rhyner (Pittcon 2013)

    Click to play  

  • DelsaMax Series - Loading

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  • DelsaMax Series - Loading Pro Only

    Click to play  

  • DelsaMax Series - Software

    Click to play  

  • DelsaMax Series - Software: Polymer Challenge Sizing & Mobility

    Click to play  

  • DelsaMax Series - Software: Protein Challenge

    Click to play  

  • Introducing DelsaMax - Life Science Connect

    Click to play  

  • Introducing DelsaMax - Pittcon 2013

    Click to play  

  • Webinars & Symposiums

  • Accurate and Reproducible Measurement of Protein Zeta Potential

    Joshua T. Robinson, Ph.D. Senior Development Scientist Beckman Coulter Life Sciences

    Click to play  

  • Advanced Process Quality Control and Outlier Detection with Discrete Particle Analysis

    Matthew N. Rhyner, Ph.D. Beckman Coulter Life Sciences

    Click to play  

  • Does Your Protein Analysis Toolbox Need a Refresh?

    Rich Jones, PhD Senior Marketing Manager; Beckman Coulter

    Click to play  

    Does your protein analysis toolbox need a refresh? Do you have a firm grasp on the tools available and when each might best be employed in your daily research activities?

    High quality proteins are critical for contemporary biomedical...

  • Pushing the Boundaries of Nanoparticle Characterization: Ultra-Fast, Simultaneous Dynamic Light Scattering and Zeta Potential

    Joshua T. Robinson, Ph.D. Senior Development Scientist Beckman Coulter Life Sciences

    Click to play  

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