The Beckman Coulter's Agencourt FormaPure® nucleic acid purification kit utilizes Beckman Coulter's patented SPRI paramagnetic bead-based technology and is specially designed to isolate total nucleic acids or total RNA from a maximum input of 5 sections of 10 μm slices of formalin-fixed, paraffin-embedded tissue. The total RNA extraction procedure was modified for micro-RNA (miRNA) purification by optimizing the formulation of the Bind Buffer, Wash Buffer and ethanol wash steps. This supplemental protocol enables recovery of miRNA, small RNA and total RNA, for applications such as RT-PCR. The protocol can be performed in a 96-well plate or in a 1.7 mL tube format. The Agencourt FormaPure procedure does not require vacuum filtration or centrifugation.