During various stages of the cell culturing process, centrifugation is frequently used to isolate extracellular products or to separate cells from their aqueous environment. Traditionally, cells and media are first transferred from a cell culture flask to a 15 mL or 50 mL conical tube before centrifugation. These transfer steps require operator labor and time, and the cost of the transfer vessel, and also introduce the potential for contamination during transfer. With the innovative Cell Culture Flask Adapters,* the culture can be centrifuged directly in the flask. Data illustrate that cell yield, cell viability, and endpoint analysis results are comparable when cell cultures are processed traditionally or centrifuged directly in the flask using Cell Culture Flask Adapters.