Bubbles create major issues when characterizing nanoparticles in solution because the characterization techniques typically utilize light scattering, specifically when determining size distribution and stability. Bubbles are much larger than nanoparticles and will scatter exponentially more light while interfering with particle movement, giving inaccurate results. Bubbles are often introduced when samples are pipetted into small cuvettes that are commonly used for dynamic light scattering (the prevailing method for calculating the size distribution of nanoparticles in solution). A larger issue is that bubbles are spontaneously formed during zeta potential measurements. Zeta (ζ) potential is a physical parameter which is representative of a particle’s surface charge and can be directly related to the particle’s stability in solution. To quantify zeta potential, a voltage is applied to the solution; the electrically directed speed of the particles is determined through a light scattering technique, known commonly as Phase-Analysis Light Scattering (PALS). Electrolysis, an insidious reaction that occurs in all zeta potential measurements, leads to bubble generation.1-4 With typical zeta potential measurements, great care and laborious workarounds are needed to avoid or eliminate bubbles.