Micro RNAs are small non-coding ribonucleic acids with sizes between 18 and 40 nucleotides (nts). The majority of miRNAs are composed of approximately 22 nts. Purification of these small miRNA fragments after enzymatic reactions can be challenging because most commonly-used column methods were designed to recover fragment sizes that are greater than 50 nts. Therefore, these column methods often produce lower miRNA yields. This application note describes the use of Beckman Coulter’s Agencourt RNAClean XP kit for miRNA clean up and concentration of miRNA and total RNA from low yield samples. The RNAClean XP kit is a Solid Phase Reverse Immobilization (SPRI) paramagnetic bead-based method for RNA and cDNA purification. The magnetic bead procedure does not require centrifugation or filtration steps.