Micro RNAs are small naturally occurring non-coding ribonucleic acids with sizes between 18 and 40 nucleotides (nts) that have been demonstrated to play a significant role in the regulation of gene expression. As a result, interest in smaller RNA species, such as miRNA, has increased. Here we describe the purification of total RNA, including miRNA and other small RNA molecules from fresh frozen tissue samples using the Agencourt SPRI (Solid Phase Reverse Immobilization) magnetic bead based chemistry. Extracting RNA from tissues often involves phenol and chloroform as well as multiple centrifugation steps. The SPRI method is an easy, rapid, high yielding, robust and automation-friendly nucleic acid purification procedure that does not require vortexing, centrifugation or filtration steps. The RNAdvance Tissue protocol has additional steps for lysing and purifying the sample. This technical note demonstrates that the SPRI extraction method produces high quality miRNA and RNA using two homogenization methods. The RNA yield and quality is comparable to a commonly used column method.